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Application of Differentiated SH-SY5Y Cells for Toxicological Studies of Alzheimer’s Amyloid Beta Peptide = Diferentseeritud SH-SY5Y rakkude kasutamine Alzheimeri amüloid beeta peptiidi toksilisuse uurimiseksKrištal, Jekaterina2020 https://digikogu.taltech.ee/et/Item/8aef400a-e1ff-4803-a0da-fc2d97c8d451

Assessing amyloid pathology in cognitively normal subjects using 18F-flutemetamol PET : comparing visual reads and quantitative methodsCollij, Lyduine E.; Konijnenberg, Elles; Reimand, Juhan; Kate, Mara ten; den Braber, Anouk; Alves, Isadora Lopes; Zwan, Marissa; Yaqub, Maqsood; van Assema, Daniëlle M.E.; Wink, Alle MeijeJournal of nuclear medicine2019 / 7 p. : ill https://doi.org/10.2967/jnumed.118.211532 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Association of amyloid-β CSF/PET discordance and tau load 5 years laterReimand, Juhan; Collij, Lyduine E.; Scheltens, PhilipNeurology2020 / p. e2648-e2657 : ill https://doi.org/10.1212/WNL.0000000000010739 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963352/ Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Berberine, a popular dietary supplement for human and animal health : quantitative research literature analysis – a reviewYeung, Andy Wai Kan; Orhan, Ilkay Erdogan; Aggarwal, Bharat Bhushan; Battino, Maurizio; Belwal, Tarun; Bishayee, Anupam; Daglia, Maria; Devkota, Hari Prasad; El-Demerdash, Amr; Balacheva, Aneliya A.; Georgieva, Maya G.; Gupta, Vijai KumarAnimal Science Papers and Reports2020 / p. 5-19 https://www.igbzpan.pl/uploaded/FSiBundleContentBlockBundleModelTranslatableBlockTranslatableFilesElement/filePath/1583/str5-20.pdf Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-[beeta] peptideTõugu, Vello; Karafin, Ann; Palumaa, PeepJournal of neurochemistry2008 / p. 1249-1259 : ill https://pubmed.ncbi.nlm.nih.gov/18289347/

Biophysical studies of the amyloid beta-peptide : interactions with metal ions and small moleculesWärmländer, Sebastian K.T.S.; Tiiman, Ann; Abelein, AxelChembiochem : a European journal of chemical biology2013 / p. 1692-1704 : ill https://doi.org/10.1002/cbic.201300262 Journal metrics at Scopud Article at Scopus Journal metrics at WOS Article at WOS

Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperativelyPalumaa, Peep; Eriste, Elo; Njunkova, Olga; Pokras, Lesja; Jornvall, H.; Sillard, RannarBiochemistry2002 / 19, p.6158-6163 https://pubmed.ncbi.nlm.nih.gov/11994011/

Characterization of Uranyl (UO22+) ion binding to Amyloid Beta (Aβ) peptides : effects on Aβ structure and aggregationBerntsson, Elina; Vosough, Faraz; Noormägi, Andra; Padari, Kärt; Asplund, Fanny; Gielnik, Maciej; Paul, Suman; Jarvet, Jüri; Tõugu, Vello; Palumaa, PeepACS chemical neuroscience2023 / p. 2618-2633 : ill https://doi.org/10.1021/acschemneuro.3c00130 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Chemical modification of met and his residues of amyloid β peptide. Influence of copper ions and effect on fibrillization = Metioniini ja histidiini jääkide keemiline modifitseerimine amüloid-β peptiidis. Vaskioonide mõju ja efekt fibrillisatsioonileSardis, Merlin2021 https://doi.org/10.23658/taltech.19/2021 https://www.ester.ee/record=b5416905*est https://digikogu.taltech.ee/et/Item/acced69c-c690-4cb5-a972-48e1c4ae5c66

Coordination of zinc ions to the key proteins of neurodegenerative diseases: A[beeta], APP, [alfa]-synuclein and PrPTõugu, Vello; Palumaa, PeepCoordination chemistry reviews2012 / p. 2219-2224 : ill https://www.researchgate.net/publication/236131300_Coordination_of_zinc_ions_to_the_key_proteins_of_neurodegenerative_diseases_Ab_APP_a-synuclein_and_PrP

Copper(II) ions and the Alzheimer's amyloid-β peptide : affinity and stoichiometry of bindingTõugu, Vello; Friedemann, Merlin; Tiiman, Ann; Palumaa, PeepAIP conference proceedings2014 / p. 109-111

Cu(II) partially protects three histidine residues and the N-terminus of amyloid-β peptide from diethyl pyrocarbonate (DEPC) modificationFriedemann, Merlin; Tõugu, Vello; Palumaa, PeepFEBS Open Bio2020 / p. 1072-1081 https://doi.org/10.1002/2211-5463.12857 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Discordance between amyloid-β PET and CSF biomarkers : clinical and pathophysiological consequences = Amüloid-β staatuse vastuolu PET-uuringul ning liikvorianalüüsil : kliiniline ja patofüsioloogiline tähendusReimand, Juhan2021 https://doi.org/10.23658/taltech.15/2021 https://www.ester.ee/record=b5431268*est https://digikogu.taltech.ee/et/Item/d14a365f-fbfc-4595-923e-473262485fe2

Discordant amyloid-β PET and CSF biomarkers and its clinical consequencesWilde, Arno de; Reimand, Juhan; Teunissen, Charlotte E.; Zwan, MarissaAlzheimer's Research & Therapy2019 / art. 78, 13 p. : ill https://doi.org/10.1186/s13195-019-0532-x Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Doktorant loodab vase reguleerimisega Alzheimerit ennetadaFilippov, Madismed24.ee2023 Doktorant loodab vase reguleerimisega Alzheimerit ennetada

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Effect of agitation on the peptide fibrillization: Alzheimer’s amyloid- b peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditionsTiiman, Ann; Noormägi, Andra; Friedemann, Merlin; Krištal, Jekaterina; Palumaa, Peep; Tõugu, VelloJournal of peptide science2013 / p. 386-391 : ill https://doi.org/10.1002/psc.2513 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Effect of methionine-35 oxidation on the aggregation of amyloid-β peptideFriedemann, Merlin; Helk, Eneken; Tiiman, Ann; Zovo, Kairit; Palumaa, Peep; Tõugu, VelloBiochemistry and biophysics reports2015 / p. 94-99 : ill http://dx.doi.org/10.1016/j.bbrep.2015.07.017

Estonian scientists' find could pave the way for new depression treatmenterr.ee2025 https://news.err.ee/1609664915/estonian-scientists-find-could-pave-the-way-for-new-depression-treatment https://doi.org/10.1523/JNEUROSCI.0313-24.2025

Identifying the role of co-aggregation of Alzheimer's amyloid-β with amorphous protein aggregates of non-amyloid proteinsWu, Jinming; Österlund, Nicklas; Wang, Hongzhi; Sternke-Hoffmann, R.; Pupart, Hegne; Ilag, Leopold L.; Gräslund, Astrid; Luo, JinghuiCell Reports Physical Science2022 / art. 101028 https://doi.org/10.1016/j.xcrp.2022.101028 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cellsKrishtal, Jekaterina; Bragina, Olga; Metsla, Kristel; Palumaa, Peep; Tõugu, VelloPLoS ONE2017 / art. e0186636, 16 p. : ill https://doi.org/10.1371/journal.pone.0186636 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

In vitro fibrillization of Alzheimer's amyloid-β peptide (1-42)Tiiman, Ann; Krištal, Jekaterina; Palumaa, Peep; Tõugu, VelloAIP advances2015 / p. 092401-1 - 092401-12 : ill https://doi.org/10.1063/1.4921071 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Interaction between oligomers of stefin B and amyloid-[beeta] in vitro and in cellsŠkerget, Katja; Taler-Veričič, Ajda; Kumm, Tiina; Palumaa, PeepJournal of biological chemistry2010 / 5, p. 3201-3210 https://pubmed.ncbi.nlm.nih.gov/19955183/

Interactions of Alzheimer's amyloid-ß peptides with Zn(II) and Cu(II) ions = Alzheimeri amüloid-ß peptiidide interaktsioonid Zn(II) ja Cu(II) ioonidegaTiiman, Ann2012 https://www.ester.ee/record=b2866174*est

Interactions of metal ions with peptides and proteins related to Alzheimer's disease = Metallioonide interaktsioonid Alzheimeri tõvega seotud peptiidide ja valkudegaBerntsson, Elina2025 https://www.ester.ee/record=b5720764*est https://doi.org/10.23658/taltech.5/2025 https://digikogu.taltech.ee/et/Item/ccd57cc9-0670-4c08-b9b8-9bc359475486

Interactions of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-B peptide in vitroKarafin, Ann; Palumaa, Peep; Tõugu, VelloFEBS journal2008 / Suppl. 1, p. 222

Interactions of Zn(II) and Cu(II) ions with Alzheimer’s amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicityTõugu, Vello; Tiiman, Ann; Palumaa, PeepMetallomics2011 / p. 250-261 : ill https://academic.oup.com/metallomics/article/3/3/250/6016214

Label-free high-throughput screening assay for inhibitors of Alzheimer's amyloid-[beeta] peptide aggregation based on MALDI MSZovo, Kairit; Helk, Eneken; Karafin, Ann; Tõugu, Vello; Palumaa, PeepAnalytical chemistry2010 / p. 8558-8565 https://www.researchgate.net/publication/46392320_Label-Free_High-Throughput_Screening_Assay_for_Inhibitors_of_Alzheimer's_Amyloid-beta_Peptide_Aggregation_Based_on_MALDI_MS

Lithium ions display weak interaction with amyloid-beta (Aβ) peptides and have minor effects on their aggregationBerntsson, Elina; Paul, Suman; Vosough, Faraz; Sholts, Sabrina B.; Jarvet, Jüri; Roos, Per M.; Barth, Andreas; Gräslund, Astrid; Wärmländer, Sebastian K.T.S.Acta biochimica Polonica2021 / p. 169-179 https://doi.org/10.18388/abp.2020_5493 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Looduslik toidulisand võib aidata Alzheimeri tõve ennetada = Эстонские ученые исследуют новый способ борьбы с болезнью АльцгеймераKirss, Sigridnovaator.err.ee2024 Looduslik toidulisand võib aidata Alzheimeri tõve ennetada Эстонские ученые исследуют новый способ борьбы с болезнью Альцгеймера

Medical plants and nutraceuticals for amyloid-β fibrillation inhibitionWitter, Steffi; Witter, Raiker; Vilu, Raivo; Samoson, AgoJournal of Alzheimer's Disease Reports2018 / p. 239-252 : ill http://doi.org/10.3233/ADR-180066

Mercury and Alzheimer’s disease: Hg(II) ions display specific binding to the amyloid-β peptide and hinder its fibrillizationWallin, Cecilia; Friedemann, Merlin; Sholts, Sabrina B.; Noormägi, Andra; Svantesson, Teodor; Järvet, Jüri; Roos, Per M.; Palumaa, Peep; Gräslund, Astrid; Wärmländer, Sebastian K.T.S.Biomolecules2020 / art. 44, 23 p. : ill https://doi.org/10.3390/biom10010044 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Metabolism of copper and possibilities for its regulationPalumaa, PeepProceedings of the Estonian Academy of Sciences2023 / p. 382-392 https://doi.org/10.3176/proc.2023.4.03 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Metal binding of metallothionein-3 versus metallothionein-2 : lower affinity and higher plasticityPalumaa, Peep; Tammiste, Indrek; Kruusel, Keiu; Kangur, Liina; Jörnvall, Hans; Sillard, RannarBiochimica et biophysica acta : proteins and proteomics2005 / 2, p. 205-211 : ill https://www.sciencedirect.com/science/article/pii/S1570963904003164

Metal binding to brain-specific metallothionein-3 studied by electrospray ionization mass spectrometryPalumaa, Peep; Eriste, Elo; Kruusel, Keiu; Kangur, Liina; Jörnvall, Hans; Sillard, RannarCellular and molecular biology2003 / 5, p. 763-768 https://pubmed.ncbi.nlm.nih.gov/14528913/

Oxidation of Methionine-35 in Alzheimer's amyloid-beta peptide and the aggregation of the oxidized peptideFriedemann, Merlin; Helk, Eneken; Tiiman, Ann; Zovo, Kairit; Palumaa, Peep; Tõugu, VelloSpringerPlus2015 / p. 20, P13 http://dx.doi.org/10.1186/2193-1801-4-S1-P13

Porfüriinid ja bilirubiin pärsivad Alzheimeri amüloid beta peptiidi agregatsiooniTšekulajeva, Ludmilla; Ševtšuk, Igor; Tšekulajev, Vladimir; Palumaa, PeepXXX Eesti keemiapäevad : teaduskonverentsi teesid = 30th Estonian Chemistry Days : abstracts of scientific conference2007 / lk. 165-166 https://www.ester.ee/record=b2314480*est

Posterioorne kortikaalne atroofia – nägemishäirena avalduva varajase algusega Alzheimeri tõve haigusjuhu kirjeldusReimand, Juhan; Zopp, Mairi; Varus, Heivi; Gross-Paju, KatrinEesti Arst2019 / lk. 664-668 : ill http://www.ester.ee/record=b1072028*est http://eestiarst.ee/posterioorne-kortikaalne-atroofia-nagemishairena-avalduva-varajase-algusega-alzheimeri-tove-haigusjuhu-kirjeldus/

Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptidesBerntsson, Elina; Vosough, Faraz; Svantesson, Teodor; Pansieri, Jonathan; Iashchishyn, Igor A.; Ostojić, Lucija; Dong, Xiaolin; Paul, Suman; Jarvet, Jüri; Roos, Per M.; Gräslund, Astrid; Wärmländer, Sebastian K.T.S.Scientific Reports2023 / art. 3341 https://doi.org/10.1038/s41598-023-29901-5 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Silmatorkamatu DNA jupp võib kujutada võtit ajuhaiguste leevendamiseksnovaator.err.ee2023 Silmatorkamatu DNA jupp võib kujutada võtit ajuhaiguste leevendamiseks Небольшой участок ДНК может стать ключом к лечению заболеваний мозга

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's diseaseVisser, Denise; Wolters, Emma E.; Verfaillie, Sander C.J.; Coomans, Emma M.; Timmers, Tessa; Tuncel, Hayel; Reimand, Juhan; Boellaard, Ronald; Windhorst, Albert D.; Scheltens, Philip; Scheltens, PhilipEuropean journal of nuclear medicine and molecular imaging2020 / p. 3165–3175 https://doi.org/10.1007/s00259-020-04831-w

Tau PET correlates with different Alzheimer’s disease-related features compared to CSF and plasma p-tau biomarkersOssenkoppele, Rik; Reimand, Juhan; Smith, Ruben; Leuzy, Antoine; Strandberg, Olof; Palmqvist, Sebastian; Stomrud, Erik; Zetterberg, HenrikEMBO Molecular Medicine2021 / art. e14398 https://doi.org/10.15252/emmm.202114398 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

The missing link in the amyloid cascade of Alzheimer's disease - metal ionsTiiman, Ann; Palumaa, Peep; Tõugu, VelloNeurochemistry international2013 / p. 367-378 : ill https://doi.org/10.1016/j.neuint.2013.01.023 https://www.sciencedirect.com/science/article/pii/S0197018613000326 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Toxicity of amyloid beta 1-40 and 1-42 on SH-SY5Y cell lineKrištal, Jekaterina; Bragina, Olga; Metsla, Kristel; Palumaa, Peep; Tõugu, VelloSpringerPlus2015 / p. 21-22, P19 http://dx.doi.org/10.1186/2193-1801-4-S1-P19

Toxicity of amyloid-β peptides varies depending on differentiation route of SH-SY5Y cellsKrištal, Jekaterina; Metsla, Kristel; Bragina, Olga; Tõugu, Vello; Palumaa, PeepJournal of Alzheimer's disease2019 / p. 879−887 https://doi.org/10.3233/JAD-190705 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Tsingi ja vase rakulised funktsioonid ja roll Alzheimeri tõve patoloogias : kommentaar Eesti Vabariigi teaduse aastapreemia pälvinud tööde tsüklilePalumaa, PeepTallinna Tehnikaülikooli aastaraamat 20112012 / lk. 193-214 : ill

TTÜ geenitehnoloogid otsivad ravimit Alzheimeri tõvelePalumaa, Peep; Helme, KristiMente et Manu2013 / lk. 14-16 : fot

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilienceKumar, Amit; Karuppagounder, Saravanan S.; Chen, Yingxin; Corona, Carlo; Kawaguchi, Riki; Chen, Yuyan; Balkaya, Mustafa; Sagdullaev, Botir T.; Wen, Zhexing; Stuart, Charles; Cho, Sunghee; Ming, Guo-li; Tuvikene, Jürgen; Timmusk, Tõnis; Geschwind, Daniel H.; Ratan, Rajiv R.Neuron2023 / p. 2831-2846 : ill https://doi.org/10.1016/j.neuron.2023.06.013 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

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α-Lipoic acid has the potential to normalize copper metabolism, which is dysregulated in Alzheimer’s diseaseMetsla, Kristel; Kirss, Sigrid; Laks, Katrina; Sildnik, Gertrud; Palgi, Mari; Palumaa, Teele; Tõugu, Vello; Palumaa, PeepJournal of Alzheimer's Disease2022 / p. 715-728 https://doi.org/10.3233/JAD-215026 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

α-Lipoic acid: a potential regulator of copper metabolism in Alzheimer’s diseaseKirss, Sigrid; Reinapu, Anette; Kabin, Ekaterina; Smirnova, Julia; Tõugu, Vello; Palumaa, PeepFrontiers in Molecular Biosciences2024 / art. 1451536 https://doi.org/10.3389/fmolb.2024.1451536