Targad analüütilised tehnoloogiad
Uurimisrühma juht
Seotud struktuuriüksus
TalTech prioriteetne teadussuund
Ülevaade
Uurimisrühma visiooniks on: “Innovation thorough the border crossing”. Uurimisrühma tuumiktehnoloogiad hõlmavad kapillaarelektroforeesi, fluorestsentsi, juhtivust, gaaskromatograafiat, mikrofluidikat ning mitmeid teisi kaasaegseid instrumentaalseid ja analüütilisi meetodeid. Rühm töötab välja analüütilisi meetodeid psühhoaktiivsete ainete tuvastamiseks ja kvantifitseerimiseks nii bioloogilistes proovides kui ka taimematerjalides. Lisaks keskendub uurimisrühm erinevate ainete farmakokineetika ja metabolismi uurimisele, et paremini mõista nende ainete mõju organismile ja vastavaid detekteerimisviise. Rühm teeb tihedat koostööd rahvusvaheliste teadustöögruppide ja partneritega üle maailma ning panustab aktiivselt erinevatesse partnerlusprojektidesse, sealhulgas Horizon Europe’i ja teistesse teadusrahastuse programmidesse. Viimase 15 aasta jooksul on rühma teadlased arendanud ja rakendanud mitmete valdkondade ja partnerite jaoks erinevaid analüsaatoreid, nagu näiteks drughunter.eu ja smagry.com. Olulisemateks koostööpartneriteks on olnud ka Eesti Politsei- ja Piirivalveamet, kellele on välja töötatud innovaatilisi lahendusi, mis vastavad nii avaliku sektori kui ka erasektori praktilistele vajadustele.
Uurimisrühma liige
Endised liikmed
Klassifikaator (Frascati)
Võtmesõna
analüsaatorid
keelatud ained
narkootilised ained
fluorestsents
Drug Hunter
kemomeetria
kvaliteedijuhtimine
täppispõllumajandus
Tähtsamad tulemused
2024. aasta peamised saavutused: (1) Uute metoodikate väljatöötamine ja täielik valideerimine tramadooli ja kodeiini monitorimiseks süljes, kasutades Drug Hunterit, vastavalt EMA ICH M10 juhendile; (2) SmartAGRO prototüübi arendamine ja edukas testimine mulla proovide analüüsiks; SmartAGRO valiti Beamline Deeptech Accelerator programmi, et tõsta selle tehnoloogilise valmiduse taset (TRL), arendada ärimudelit, suurendada nähtavust ja viia läbi pilootprojektid esimeste kasutajatega Eestis (www.smagry.com); (3) Uute analüütiliste metoodikate väljatöötamine ja testimine uutele semi-sünteetilistele kannabinoididele, sealhulgas THC-JD ja HHC; (4) Uue mini CD spektromeetri arendamine koostöös Mikrofluidika uurimisrühmaga; (5) Hargettevõtte SafePAS (www.safepas.eu [http://www.safepas.eu]) asutamine portatiivsete analüsaatorite turule viimiseks.
- Kaljurand, M., Mazina-Šinkar, J. Portable capillary electrophoresis as a green analytical technology // TrAC Trends in Analytical Chemistry (2022) vol. 157, art. 116811.
https://doi.org/10.1016/j.trac.2022.116811 - Ružicka, M., Kaljurand, M., Gorbatšova, J., Vaher, M., Mazina-Šinkar, J. Portable fully automated oral fluid extraction device for illegal drugs // Talanta (2022) vol. 243, art. 123389.
https://doi.org/10.1016/j.talanta.2022.123389 - Bolkvadze, V., Bondar, D., Vaher, M., Halling, E., Gorbatsova, J., Mazina-Šinkar, J. The influence of organic solvents on phenylethylamines in capillary zone electrophoresis // Journal of chromatography A (2022) vol. 1675, art. 463169, 9 p. : ill.
https://doi.org/10.1016/j.chroma.2022.463169 - Ružicka, M., Kaljurand, M., Gorbatšova, J., Mazina-Šinkar, J. Autosampler for portable capillary electrophoresis // Journal of chromatography A (2022) vol. 1685, art. 463619.
https://doi.org/10.1016/j.chroma.2022.463619 - Kaljurand, M., Gorbatšova, J., Mazina-Šinkar, J. A gas chromatograph for citizen science // Microchemical journal (2021) vol. 165, art. 106195, 6 p. : ill.
https://doi.org/10.1016/j.microc.2021.106195 - Kaljurand, M., Saar-Reismaa, P., Vaher, M., Gorbatšova, J., Mazina-Šinkar, J. Capillary electrophoresis as a monitoring tool for flow composition determination // Molecules (2021) vol. 26, 16, art. 4918, 12 p. : ill.
https://doi.org/10.3390/molecules26164918 - Koel, M., Kuhtinskaja, M., Vaher, M. Extraction of bioactive compounds from Catharanthus roseus and Vinca minor // Separation and purification technology (2020) vol. 252, 1, art. 117438 ; 5 p. : ill.
https://doi.org/10.1016/j.seppur.2020.117438 - Saar-Reismaa, P., Brilla, C.A., Leiman, K., Kaljurand, M., Vaher, M., Kulp, M., Mazina-Šinkar, J. Use of a newly-developed portable capillary electrophoresis analyser to detect drugs of abuse in oral fluid: A case study // Talanta (2020) vol. 211, art. 120662, 9 p.
https://doi.org/10.1016/j.talanta.2019.120662 - Jõul, P., Vaher, M., Kuhtinskaja, M. Carbon aerogel-based solid-phase microextraction coating for the analysis of organophosphorus pesticides // Analytical methods (2021) vol. 13, 1, p. 69−76 : ill.
https://doi.org/10.1039/D0AY02002H - Drevinskas, T., Maruška, A., Girdauskas, V., Dūda, G., Gorbatsova, J., Kaljurand, M. Complete capillary electrophoresis process on a drone : towards a flying micro-lab // Analytical Methods (2020) Vol. 12, 41, p. 4977 - 4986.
https://doi.org/10.1039/d0ay01220c - Saar-Reismaa, P., Kotkas, K., Rosenberg, V., Kulp, M., Kuhtinskaja, M., Vaher, M. Analysis of total phenols, sugars, and mineral elements in colored tubers of solanum tuberosum l. // Foods (2020) vol. 9, 12, art. 1862.
https://doi.org/10.3390/foods9121862 - Saar-Reismaa, P., Koel, M., Tarto, R., Vaher, M. Extraction of bioactive compounds from Dipsacus fullonum leaves using deep eutectic solvents // Journal of chromatography A (2022) vol. 1677, art. 463330.
https://doi.org/10.1016/j.chroma.2022.463330 - Koel, M., Kaljurand, M. Editorial overview : a closer look on green developments in analytical chemistry: green analytical chemistry is going mainstream // Current Opinion in Green and Sustainable Chemistry (2021) vol. 31, Art. 100541.
https://doi.org/10.1016/j.cogsc.2021.100541 - Kuhtinskaja, M., Bragina, O., Kulp, M., Vaher, M. Anticancer Effect of the Iridoid Glycoside Fraction from Dipsacus fullonum L. Leaves // Natural product communications (2020) vol. 15, 9, p. 1-6.
https://doi.org/10.1177/1934578X20951417 - Berber, H., Tamm, K., Leinus, M-L., Kuusik, R., Tõnsuaadu, K., Paaver, P., Uibu, M. Accelerated carbonation technology granulation of industrial waste : effects of mixture composition on product properties // Waste management & research (2020) vol. 38, 2, p. 142-155.
https://doi.org/10.1177/0734242X19886646 - Saar-Reismaa, P., Bragina, O., Kuhtinskaja, M., Reile, I., Laanet, P.-R., Kulp, M., Vaher, M. Extraction and fractionation of bioactives from Dipsacus fullonum L. leaves and evaluation of their anti-borrelia activity // Pharmaceuticals (2022) vol. 15, 1, 12 p. : ill.
https://doi.org/10.3390/ph15010087 - Laanet, P.-R., Vaher, M., Saar-Reismaa, P. Micellar electrokinetic chromatography method for the analysis of synthetic and phytocannabinoids // Journal of chromatography A (2022) vol. 1673, art. 463080.
https://doi.org/10.1016/j.chroma.2022.463080 - Bimbiraite-Surviliene, K., Drevinskas, T., Maruska, A., Gorbatsova, J., Kaljurand, M. et al. Portable automated handheld sample collection-preparation instrument for airborne volatile substances // Microchemical journal (2020) vol. 159, art. 105576.
https://doi.org/10.1016/j.microc.2020.105576 - Drevinskas, T., Maruška, A., Naujokaitytė, G., Telksnys, L., Kaljurand, M., Stanys, V., Cowles, J., Gorbatsova, J. Towards adaptive method for peak migration time correction : discretization period in electropherograms // Chemija (2020) vol. 31, 3, p. 146-155 : ill.
https://doi.org/10.6001/CHEMIJA.V31I3.4288 - Lees, H., Jõul, P., Siilak, K., Vaher, M. Separation of perfluoroalkyl substances by using nonaqueous capillary electrophoresis with conductivity detection // Separation science plus (2020) vol. 3, 7, p. 313-320.
https://doi.org/10.1002/sscp.202000016 - Berber, H., Tamm, K., Leinus, M.-L., Kuusik, R., Uibu, M. Aggregate production from burnt oil shale and CO2 - an Estonian perspective // Oil Shale (2019) vol. 36, 3, p. 431-447 : ill.
https://doi.org/10.3176/oil.2019.3.05 http://www.kirj.ee/32493/?tpl=1061&c_tpl=1064 - Lees, H., Zapata, F., Vaher, M., García-Ruiz, C. Study of the adhesion of explosive residues to the finger and transfer to clothing and luggage // Science & Justice (2018) vol. 58, 6, p. 415-424.
https://doi.org/10.1016/j.scijus.2018.07.002 - Lees, H., Zapata, F., Vaher, M., García-Ruiz, C. Simple multispectral imaging approach for determining the transfer of explosive residues in consecutive fingerprints // Talanta (2018) vol. 184, p. 437-445 : ill.
https://doi.org/10.1016/j.talanta.2018.02.079 - Söderström, M., Östin, A., Vaher, M., Jõul, P., Lees, H., Kaljurand, M. et al. Chemical analysis of dumped chemical warfare agents during the MODUM project // Towards the monitoring of dumped munitions threat (MODUM) : a study of chemical munitions dumpsites in the Baltic Sea. Dordrecht : Springer, 2018. p. 71-103. (NATO science for peace and security series. C, Environmental security).
https://doi.org/10.1007/978-94-024-1153-9_4 - Aid, T., Koel, M., Lopp, M., Vaher, M. Metal-catalyzed degradation of cellulose in ionic liquid media // Inorganics (2018) vol. 6, 3, art. 78, 11 p. : ill.
https://doi.org/10.3390/inorganics6030078 - Kaljurand, M. Paper microzones as a route to greener analytical chemistry // Current Opinion in Green and Sustainable Chemistry (2019) Vol. 19, p. 15-18.
https://doi.org/10.1016/j.cogsc.2019.03.002 - Jõul, P., Vaher, M., Kuhtinskaja, M. Evaluation of carbon aerogel-based solid-phase extraction sorbent for the analysis of sulfur mustard degradation products in environmental water samples // Chemosphere (2018) Vol. 198, p. 460-468.
https://doi.org/10.1016/j.chemosphere.2018.01.157 - Drevinskas, T., Telksnys, L., Maruška, A., Gorbatšova, J., Kaljurand, M. Compensation of the baseline temperature fluctuations for autonomous CE–C4D instrument working in harsh environments // Electrophoresis (2018) vol. 39, 22, p. 2877–2883 : ill.
https://doi.org/10.1002/elps.201800132 - Drevinskas, T., Telksnys, L., Maruška, A., Gorbatšova, J., Kaljurand, M. Capillary electrophoresis sensitivity enhancement based on adaptive moving average method // Analytical chemistry (2018) vol. 90, 11, p. 6773−6780 : ill.
https://doi.org/10.1021/acs.analchem.8b00664 - Saar-Reismaa, P., Tretjakova, A., Mazina-Šinkar, J., Vaher, M., Kaljurand, M., Kulp, M. Rapid and sensitive capillary electrophoresis method for the analysis of Ecstasy in an oral fluid // Talanta (2019) vol. 197, p. 390-396 : ill.
https://doi.org/10.1016/j.talanta.2019.01.029 - Saar-Reismaa, P., Erme, E., Vaher, M., Kulp, M., Kaljurand, M., Mazina-Šinkar, J. In situ determination of illegal drugs in oral fluid by portable capillary electrophoresis with deep UV excited fluorescence detection // Analytical chemistry (2018) vol. 90, 10, p. 6253-6258 : ill.
https://doi.org/10.1021/acs.analchem.8b00911 - Kaljurand, M., Růžička, M., Gorbatsova, J., Mazina-Šinkar, J. Evaluation of different operating modes of an autosampler for portable capillary electrophoresis // Journal of Chromatography A (2023) vol. 1705, art. 464201.
https://doi.org/10.1016/j.chroma.2023.464201 - Kaljurand, M., Ružička, M., Gorbatšova, J., Mazina-Šinkar, J. New developments in separation science will help to contribute to the democratisation of analytical chemistry // Microchemical journal (2023) vol. 195, Art. 109443.
https://doi.org/10.1016/j.microc.2023.109443