Synthetic flow chemistry group
TalTech priority area
Research classification (Frascati)
Head of the research group
Research group member
Doctoral students
Keyword
electrochemistry
photochemistry
organic synthesis
flow chemistry
asymmetric catalysis
Overview
The research in the group is focused on thedevelopment of new electro- and photochemicaltransformation in continuous-flow. Our researchis multidisciplinary, as we combine modernorganic synthesis techniques with chemicalengineering in order to achieve high efficiencyand sustainability. In electro- and photochemical reactions, electricity or light are used as traceless and green reagents to generate highlyreactive species under mild reaction conditions,which gives access to the new reaction pathways.Moreover, the potential to harvest sustainableelectricity from solar or wind energy and usingdaylight directly to perform reactions makeselectro- and photochemistry highly attractive.In our group, we perform such transformationnot in conventional chemical flask or test tubes,but in specially designed flow photo- and electromicroreactors, where solution of chemicals iscontinuously pumped through the active reactorzone. Due to the continuous nature of the process, such transformations are easy to scale upmerging the gap between academia and chemical industry.
Related projects
Related department
- Kooli, A., Wesenberg, L., Beslać, M., Krech, A., Lopp, M., Noël, T., Ošeka, M. Electrochemical hydroxylation of electron-rich arenes in continuous flow // European journal of organic chemistry (2022) vol. 2022, 20, art. e202200540.
https://doi.org/10.1002/ejoc.202200011 - Ošeka, M., Kimm, M., Kaabel, S., Järving, I., Rissanen, K., Kanger, T. Asymmetric organocatalytic wittig [2,3]-rearrangement of oxindoles // Organic letters (2016) vol. 18, 6, p. 1358-1361 : ill.
https://doi.org/10.1021/acs.orglett.6b00291 - Ošeka, M., Laudadio, G., van Leest, N., Dyga, M., Bartolomeu, A. de A., Gooßen, L.J., de Bruin, B., de Oliveira, K.T., Noël, T. Electrochemical aziridination of internal alkenes with primary amines // Chem (2021) Vol. 7, Issue 1, p. 255 - 266.
https://doi.org/10.1016/j.chempr.2020.12.002 - Spinnato, D., Schweitzer-Chaput, B., Goti, G., Ošeka, M., Melchiorre, P A photochemical organocatalytic strategy for the α-alkylation of ketones by using radicals // Angewandte Chemie international Edition (2020) Vol. 59, 24, p. 9485 - 9490.
https://doi.org/10.1002/anie.201915814 - Ivanova, L., Rausalu, K., Ošeka, M., Kananovich, D. G., Žusinaite, E., Tammiku-Taul, J., Lopp, M., Merits, A., Karelson, M. Novel analogues of the Chikungunya virus protease inhibitor: molecular design, synthesis, and biological evaluation // ACS omega (2021) vol. 6, 16, p. 10884–10896.
https://doi.org/10.1021/acsomega.1c00625 - Kimm, M., Järving, I., Ošeka, M., Kanger, T. Asymmetric organocatalytic [2,3]-Wittig rearrangement of cyclohexanone derivatives // European journal of organic chemistry (2021) 21, p. 3113−3120 : ill.
https://doi.org/10.1002/ejoc.202100435 - Kimm, M., Ošeka, M., Kaabel, S., Metsala, A., Järving, I., Kanger, T. [2,3]-Wittig rearrangement as a formal asymmetric alkylation of α-branched ketones // Organic letters (2019) vol. 21, 13, p. 4976-4980.
https://doi.org/10.1021/acs.orglett.9b01495 - Krech, A., Yakimchyk, V., Jarg, T., Kananovich, D., Ošeka, M. Ring-opening coupling reaction of cyclopropanols with electrophilic alkenes enabled by decatungstate as photoredox catalyst // Advanced synthesis & catalysis (2023)
https://doi.org/10.1002/adsc.202300939 - Ramkumar, N., Plantus, K., Ozola, M., Mishnev, A., Nikolajeva, V., Senkovs, M., Ošeka, M., Veliks, J. Photoredox-catalyzed direct C–H monofluoromethylation of heteroarenes // New journal of chemistry (2023) vol. 47, 44, p. 20642-20652.
https://doi.org/10.1039/D3NJ04313D