Sensortehnoloogiad meditsiinitehnikas
TalTech prioriteetne teadussuund
Klassifikaator (Frascati)
Uurimisrühma juht
Uurimisrühma liige
Võtmesõna
algoritmid
sensorite integratsioon
biovedelike optika
ureemilised toksiinid
dialüüsravi
reaalajas monitooring
spektrofotomeetria
spektrofluorimeetria
tark töörõivas
füüsilise aktiivsuse monitooring
energiakulu
väsimuse monitooring
kõnetuvastus
Ülevaade
Uurimisgrupi teadustöö eesmärgiks on välja töötada paindlikke ja uudseid sensortehnoloogiaid ja algoritme: (1) Ureemiliste toksiinide eemaldamise jälgimiseks reaalajas. Mõõdetud parameetrid võimaldavad hinnata erinevate ureemiliste toksiinide kontsentratsioone reaalajas ilma vereproove võtmata ning seega aitab saada paremini tagasisidet ravi (n neeruasendusravi) kohta ning kohandada raviviise vastavalt patsientide vajadustega. (2) Isikustatud ja targa töörõiva loomiseks, mis töörõivasse integreeritud sensorite ja uudsete algoritmide abil looks väärtuslikke andmeid tööliste asukohast, kõnnimustritest, füüsilisest aktiivsusest, energiakulust ja füsioloogilisest seisundist ning parandaks tehnoloogiliste lahenduste ja teenuste abil teadlikkust ja ohutust nõudlikes ja ohtlikes töökeskkondades. (3) Uuenduslike psühhofüsioloogiliste meetodite väljatöötamine, mis ühendab kvantitatiivseid füsioloogilisi ja subjektiivseid psühholoogilisi näitajaid, et hinnata inimeste emotsionaalset vastust erinevatele (elu)keskkondadele (nt turvalised, mugavad, stressirohked, ülestimuleerivad või ebaatraktiivsed). Üks rakendusvaldkond on ületada lõhe linnaplaneerijate ja linnaelanike vahel kasutades nn heaoluskoori kaardistamist.
Tähtsamad tulemused
Esmakordselt õnnestus rahvusvahelise teadusuuringu tulemusena näidata, kui suur on UV-kiirgust neelavate ravimite, nagu paratsetamool (Par), manustamise mõju ureemiliste toksiinide kusihappe (UA) ja indoksülsulfaadi (IS) eemaldamise optilise seire täpsusele standardsel hemodialüüsravil (HD) ja hemodiafiltratsiooniravil (HDF).
Seotud projektid
Seotud struktuuriüksus
Teadusgrupiga seotud publikatsioonid
- Adoberg, A., Paats, J., Arund, J., Dhondt, A., Fridolin, I., Glorieux, G., Holmar, J., Lauri, K., Leis, L., Luman, M., Pilt, K., Uhlin, F., Tanner, R. Treatment with paracetamol can interfere with the intradialytic optical estimation in spent dialysate of uric acid but not of indoxyl sulfate // Toxins (2022) vol. 14, 9, art. 610.
https://doi.org/10.3390/toxins14090610 - Allik, A., Pilt, K., Viigimäe, M., Fridolin, I., Jervan, G. A novel physical fatigue assessment method utilizing heart rate variability and pulse arrival time towards personalized feedback with wearable sensors // Sensors (2022) vol. 22, 4, art. 1680.
https://doi.org/10.3390/s22041680 - Vlahou, A., Hallinan, D., Apweiler, R., Fridolin, I. et al. Data sharing under the general data protection regulation : time to harmonize law and research ethics? // Hypertension (2021) vol. 77, 4, p. 1029-1035.
https://doi.org/10.1161/HYPERTENSIONAHA.120.16340 - Paats, J., Adoberg, A., Arund, J., Fridolin, I., Lauri, K., Leis, L., Luman, M., Tanner, R. Optical method and biochemical source for the assessment of the middle-molecule uremic toxin β2-microglobulin in spent dialysate // Toxins (2021) vol. 13, 4, art. 255, 15 p. : ill.
https://doi.org/10.3390/toxins13040255 - Kööts, K., Pilt, K., Sepa, M., Pikta, M., Fridolin, I., Meigas, K., Viigimaa, M. Assessment of associations between arterial mechanical properties and biochemical blood markers for early detection of atherosclerosis // 8th European Medical and Biological Engineering Conference : proceedings of the EMBEC 2020, November 29 – December 3, 2020 Portorož, Slovenia. Cham : Springer, 2021. p. 121-129. (IFMBE proceedings ; 80).
https://doi.org/10.1007/978-3-030-64610-3_15 - Charlton, P. H., Paliakaite, B., Pilt, K., Bachler, M., Zanelli, S., Kulin, D., Allen, J., Hallab, M., Bianchini, E., Mayer, C. C. et al. Assessing hemodynamics from the photoplethysmogram to gain insights into vascular age : a review from VascAgeNet // American journal of physiology-heart and circulatory physiology (2022) vol. 322, 4, p. H493-H522.
https://doi.org/10.1152/ajpheart.00392.2021 - Uhlin, F., Szpirt, W., Kronbichler, A., Bruchfeld, A., Soveri, I., Rostaing, L., Daugas, E., Lionet, A., Kamar, N., Rafat, C. et. al. Endopeptidase cleavage of anti-glomerular basement membrane antibodies in vivo in severe kidney disease : an open-label phase 2a study // Journal of the American Society of Nephrology (2022) vol. 33, 4, p. 829-838.
https://doi.org/10.1681/ASN.2021111460 - Pépin, M., Ferreira, A.C., Arici, M., Bachmann, M., Barbieri, M., Bumblyte, I.A. et al. Cognitive disorders in patients with chronic kidney disease : specificities of clinical assessment // Nephrology Dialysis Transplantation (2022) vol. 37, p. ii23-ii32.
https://doi.org/10.1093/ndt/gfab262 - Lauri, K., Arund, J., Holmar, J., Tanner, R., Kalle, S., Luman, M., Fridolin, I. Removal of Urea, beta 2-Microglobulin, and Indoxyl Sulfate Assessed by Absorbance and Fluorescence in the Spent Dialysate During Hemodialysis // Asaio journal (2020) vol. 66, 6, p. 695−705.
https://doi.org/10.1097/MAT.0000000000001058 - Holmar, J., de la Puente-Secades, S., Floege, J., Noels, H., Jankowski, J., Orth-Alampour, S. Uremic toxins affecting cardiovascular calcification: a systematic review // Cells (2020) vol. 9, 11, art. 2428, 22 p.
https://doi.org/10.3390/cells9112428 - Holmar, J., Noels, H.; Böhm, M.; Bhargava, S.; Jankowski, J.; Orth-Alampour, S. Development, establishment and validation of in vitro and ex vivo assays of vascular calcification // Biochemical and biophysical research communications (2020) vol. 530, 2, p. 462-470.
https://doi.org/10.1016/j.bbrc.2020.05.085 - Paats, J., Arund, J., Fridolin, I., Leis, L., Luman, M., Pilt, K., Uhlin, F. et al. Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients // International journal of molecular sciences (2020) vol. 21, 4, art. 1522, 19 p. : ill.
https://doi.org/10.3390/ijms21041522 - Martinsson, C., Uhlin, F., Wenemark, M., Eldh. A. C. Preference-based patient participation for most, if not all : a cross-sectional study of patient participation amongst persons with end-stage kidney disease // Health expectations (2021) vol. 24, 5, p. 1833-1841.
https://doi.org/10.1111/hex.13323 - Ademola, O. A., Leier, M., Petlenkov, E. Evaluation of deep neural network compression methods for edge devices using weighted score-based ranking scheme // Sensors (2021) vol. 21, 22, art. 7529.
https://doi.org/10.3390/s21227529 - Staaf, K., Fernström, A., Uhlin, F. Cannulation technique and complications in arteriovenous fistulas : a Swedish Renal Registry-based cohort study // BMC Nephrology (2021) vol. 22, 1, art. 256.
https://doi.org/10.1186/s12882-021-02458-z - Årestedt, L., Martinsson, C., Hjelm, C., Uhlin, F. et al. Context Factors Facilitating and Hindering Patient Participation in Dialysis Care: A Focus Group Study With Patients and Staff // Worldviews on evidence-based nursing (2020) vol. 17, 6, p. 457-464.
https://doi.org/10.1111/wvn.12452 - Charlton, P.H., Pilt, K., Kyriacou, P.A. Establishing best practices in photoplethysmography signal acquisition and processing // Physiological measurement (2022) vol. 43, 5, art. 050301, 6 p.
https://doi.org/10.1088/1361-6579/ac6cc4 - Zemtsovskaja, G., Pilt, K., Samarin, A., Abina, J., Meigas, K., Viigimaa, M. Construction of gender-specific regression models for aortic length estimation based on computed tomography images // Health and technology (2020) vol. 10, p. 679–687 : ill.
https://doi.org/10.1007/s12553-019-00391-8 - Chesnaye, N.C., Al-Sodany, E., Szummer, K., Barany, P., Heimbürger, O., Almquist, T., Melander, S., Uhlin, F., Dekker, F., Wanner, C., Jager, K.J., Evans, M. Association of Longitudinal High-Sensitivity Troponin T with mortality in patients with chronic kidney disease // Journal of the American College of Cardiology (2022) vol. 79, 4, p. 327-336 : ill.
https://doi.org/10.1016/j.jacc.2021.11.023 - Pilt, K., Arund, J., Adoberg, A., Leis, L., Luman, M., Fridolin, I. Online urea concentration estimation from spent dialysate using optical sensor // XV Mediterranean Conference on Medical and Biological Engineering and Computing - MEDICON 2019 : proceedings of MEDICON 2019, September 26–28, 2019, Coimbra, Portugal. Cham : Springer, 2020. p. 1459-1464. (IFMBE proceedings ; 76).
https://doi.org/10.1007/978-3-030-31635-8_180 - Allik, A., Pilt, K., Viigimäe, M., Fridolin, I. Pilot study for estimating physical fatigue based on heart rate variability and reaction time // XV Mediterranean Conference on Medical and Biological Engineering and Computing -MEDICON 2019 : proceedings of MEDICON 2019, September 26–28, 2019, Coimbra, Portugal. Cham : Springer, 2020. p. 193-200. (IFMBE proceedings ; 76).
https://doi.org/10.1007/978-3-030-31635-8_23 - Pilt, K., Karai, D., Bachmann, M., Gavriljuk, M., Allik, A., Uudeberg, T. Influence of mental stress on the arterial stiffness parameters detected from photoplethysmographic signal waveform // 2022 18th Biennial Baltic Electronics Conference (BEC). : IEEE, 2022. 4 p.
https://doi.org/10.1109/BEC56180.2022.9935609 - Pilt, K., May, J. M., Kyriacou, P. A. In-vitro investigation of flow profiles in arteries using the photoplethysmograph // Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). : IEEE, 2021. p. 7211-7214.
https://doi.org/10.1109/EMBC46164.2021.9629713 - Kontus, S., Reinhold, K. Health and safety management at workplaces through interactive tools // Human Interaction, Emerging Technologies and Future Applications IV :Proceedings of the 4th International Conference on Human Interaction and Emerging Technologies: Future Applications (IHIET – AI 2021), April 28-30, 2021, Strasbourg, France. Cham : Springer, 2021. p. 686−693. (Advances in intelligent systems and computing ; 1378).
https://doi.org/10.1007/978-3-030-74009-2_87 - Holmar, J., Fridolin, I., Luman, M. et al. Removal of vascular calcification inducer phosphate in different dialysis treatment modalities // World Congress on Medical Physics and Biomedical Engineering 2018 : June 3–8, 2018, Prague, Czech Republic (Vol. 3). Singapore : Springer Nature Singapore Pte Ltd, 2019. p. 143-147. (IFMBE proceedings ; 68/3).
https://doi.org/10.1007/978-981-10-9023-3_26 - Allik, A., Mägi, S., Pilt, K., Karai, D., Fridolin I., Leier, M., Jervan, G. Comparison of predictive equations for basal metabolic rate // Wireless Mobile Communication and Healthcare : 7th International Conference, MobiHealth 2017, Vienna, Austria, November 14–15, 2017 : proceedings. Cham : Springer, 2018. p. 261-264 : ill. (Lecture notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering ; 247).
https://doi.org/10.1007/978-3-319-98551-0 - Allik, A., Pilt, K., Karai, D., Fridolin, I., Leier, M., Jervan, G. Classification algorithm improvement for physical activity recognition in maritime environments // World Congress on Medical Physics and Biomedical Engineering 2018 : June 3–8, 2018, Prague, Czech Republic (Vol. 3). Singapore : Springer Nature Singapore Pte Ltd, 2019. p. 13-17. (IFMBE proceedings ; 68/3).
https://doi.org/10.1007/978-981-10-9023-3_3 - Einstein, S., Pilt, K., Palmar, M., Meigas, K., Viigimaa, M. Aortic augmentation index is dependent on bodyside in healthy young subjects // High Blood Pressure & Cardiovascular Prevention (2019) vol. 26, p. 375–382 : ill.
https://doi.org/10.1007/s40292-019-00335-3 - Kalle, S., Tanner, R., Luman, M., Fridolin, I. Free pentosidine assessment based on fluorescence measurements in spent dialysate // Blood Purification (2019) vol. 47, p. 85–93.
https://doi.org/10.1159/000493522 - Titma, T., Shin, M-J., Ludwig, C., Günther, U., Pikta, M., Zemtsovskaja, G., Viigimaa, M., Tanner, R., Samoson, A. The metabolic profile of stable ischemic heart disease by serum 1H NMR // Applied magnetic resonance (2019) vol. 50, 4, p. 527–539 : ill.
https://doi.org/10.1007/s00723-018-1084-0 - Staaf, K., Uhlin, F. Cannulation with sharp or blunt needles for haemodialysis : the importance of cannulation technique for the patient's lifeline // Journal of Vascular Access (2019) vol. 20, 2, p. 161–168 : ill.
https://doi.org/10.1177/1129729818788811 - Pilt, K., Silluta, S., Palmar, M., Karai, D., Meigas, K., Viigimaa, M. Second derivative photoplethysmographic signal analysis of differences between fingers in healthy subjects [Online resource] // BEC 2018 : 2018 16th Biennial Baltic Electronics Conference (BEC) : proceedings of the 16th Biennial Baltic Electronics Conference, October 8-10, 2018. : IEEE, 2019. 4 p.: ill.
https://doi.org/10.1109/BEC.2018.8600985 - Yngman-Uhlin, P., Kjellsdotter, A., Uhlin, F., Edéll-Gustafsson, U. Sleep quality, fatigue, and health-related quality of life in patients on initial peritoneal dialysis and multiple modalities after two years : a prospective study // Nephrology nursing journal (2019) vol. 46, 6, p. 615–649.
https://library.annanurse.org/anna/articles/2494/view - Leier, M., Jervan, G., Allik, A., Pilt, K., Karai, D., Fridolin, I. Fall detection and activity recognition system for usage in smart work-wear [Online resource] // BEC 2018 : 2018 16th Biennial Baltic Electronics Conference (BEC) : proceedings of the 16th Biennial Baltic Electronics Conference, October 8-10, 2018. : IEEE, 2018. 4 p.: ill.
https://doi.org/10.1109/BEC.2018.8600959 - Lindström, S.B., Uhlin, F., Bjarnegård, N. et al. Computer-aided evaluation of blood vessel geometry from acoustic images // Journal of ultrasound in medicine (2018) vol. 37, 4, p. 1025-1031 : ill.
https://doi.org/10.1002/jum.14439 - Uhlin, F., Fernström, A., Knapen, M.H.J. et al. Long-term follow-up of biomarkers of vascular calcification after switch from traditional hemodialysis to online hemodiafiltration // Scandinavian journal of clinical & laboratory investigation (2019) vol. 79, 3, p. 174-181.
https://doi.org/10.1080/00365513.2019.1576218 - Allik, A., Pilt, K., Karai, D., Fridolin, I., Leier, M., Jervan, G. Optimization of physical activity recognition for real-time wearable systems : effect of window length, sampling frequency and number of features // Applied sciences (2019) vol. 9, 22, art. 4833, 14 p. : ill.
https://doi.org/10.3390/app9224833 - Paats, A., Alumäe, T., Meister, E., Fridolin, I. Retrospective analysis of clinical performance of an Estonian speech recognition system for radiology : effects of different acoustic and language models // Journal of digital imaging (2018) vol. 31, 5, p. 615–621 : ill.
https://doi.org/10.1007/s10278-018-0085-8 - Arestedt, L., Martinsson, C., Hjelm, C,, Uhlin, F. et al. Patient participation in dialysis care - A qualitative study of patients' and health professionals' perspectives // Health expectations (2019) vol. 22, 6, p. 1285−1293.
https://doi.org/10.1111/hex.12966 - Soveri, I., Molne, J., Uhlin, F. et al. The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease // Kidney International (2019) vol. 96, 5, p. 1234-1238.
https://doi.org/10.1016/j.kint.2019.06.019 - Uhlin, N.C., Szummer, K., heimbürger, O., Uhlin, F. et al. Association between renal function and troponin T over time in stable chronic kidney disease patients // Journal of the American heart association (2019) vol. 8, 21, art. e013091, 18 p. : ill.
https://doi.org/10.1161/JAHA.119.013091