AP-1 transcription factors mediate BDNF-positive feedback loop in cortical neuronsTuvikene, Jürgen; Pruunsild, Priit; Orav, Ester; Esvald, Eli-Eelika; Timmusk, TõnisJournal of neuroscience2016 / p. 1290-1305 : ill https://doi.org/10.1523/JNEUROSCI.3360-15.2016

Bioinformaatika pakub võimalust vähi ja ajuhaiguste seljatamiseksAlvela, Ainnovaator.err.ee2023 Bioinformaatika pakub võimalust vähi ja ajuhaiguste seljatamiseks

Bioinformaatika püüab antikehi uurides leida uudseid ravimeetodeidAlvela, AinTööstusEST2023 / lk. 24-26 : portr https://www.ester.ee/record=b4481084*est

CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neuronsEsvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex; Patil, Sudarshan; Bramham, Clive; Timmusk, TõnisJournal of neuroscience2020 / p. 1405-1426 : ill https://doi.org/10.1523/JNEUROSCI.0367-19.2019 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteomeTamberg, Laura; Jaago, Mariliis; Säälik, Kristi; Sirp, Alex; Tuvikene, Jürgen; Šubina, Anastassia; Kiir, Carl Alexander; Nurm, Kaja; Sepp, Mari; Timmusk, Tõnis; Palgi, MariDisease Models & Mechanisms2020 / art. dmm042747, 15 p. : ill https://doi.org/10.1242/dmm.042747 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsJaago, Mariliis; Rähni, Annika; Pupina, Nadezda; Sadam, Helle; Tuvikene, Jürgen; Avarlaid, Annela; Planken, Anu; Planken, Margus; Haring, Liina; Vasar, Eero; Bacevic, Miljana; Lambert, France; Kalso, Eija; Pussinen, Pirkko; Tienari, Pentti J.; Vaheri, Antti; Lindholm, Dan; Timmusk, Tõnis; Ghaemmaghami, Amir M.; Palm, KaiaScientific reports2022 / art. 16817 : ill https://doi.org/10.1038/s41598-022-20849-6 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Differential regulation of the BDNF gene in cortical and hippocampal neuronsEsvald, Eli-Eelika; Tuvikene, Jürgen; Moistus, Andra; Rannaste, Käthy; Kõomägi, Susann; Timmusk, TõnisJournal of neuroscience2022 / p. 9110-9128 https://doi.org/10.1523/JNEUROSCI.2535-21.2022 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Dissecting stimulus-dependent transcription of brain-derived neurotrophic factor = Aju-päritolu neurotroofse teguri stiimulsõltuva transkriptsiooni uuringudEsvald, Eli-Eelika2023 https://doi.org/10.23658/taltech.32/2023 https://digikogu.taltech.ee/et/Item/6222c009-c82d-4efb-98c2-51bf2f148b52 https://www.ester.ee/record=b5567508*est

Dopamine cross‐reacts with adrenoreceptors in cortical astrocytes to induce BDNF expression, CREB signaling and morphological transformationKoppel, Indrek; Jaanson, Kaur; Klasche, Airi; Tuvikene, Jürgen; Tiirik, Tõnis; Pärn, Angela; Timmusk, TõnisGLIA2018 / p. 206-216 : ill https://doi.org/10.1002/glia.23238 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Efficient use of a translation start codon in BDNF exon IKoppel, Indrek; Tuvikene, Jürgen; Lekk, Ingrid; Timmusk, TõnisJournal of neurochemistry2015 / p. 1015-1025 : ill http://dx.doi.org/10.1111/jnc.13124

An 840 kb distant upstream enhancer is a crucial regulator of catecholamine-dependent expression of the BDNF gene in astrocytesAvarlaid, Annela; Esvald, Eli-Eelika; Koppel, Indrek; Parkman, Annabel; Zhuravskaya, Anna; Makeyev, Eugene V.; Tuvikene, Jürgen; Timmusk, TõnisGlia2023 https://doi.org/10.1002/glia.24463

Electrochemical sensor based on molecularly imprinted polymer for rapid quantitative detection of brain-derived neurotrophic factorAyankojo, Akinrinade George; Boroznjak, Roman; Reut, Jekaterina; Tuvikene, Jürgen; Timmusk, Tõnis; Sõritski, VitaliSensors and Actuators B: Chemical2023 / art. 134656 https://doi.org/10.1016/j.snb.2023.134656

Expression of alternative transcription factor 4 mRNAs and protein isoforms in the developing and adult rodent and human tissuesSirp, Alex; Shubina, Anastassia; Tuvikene, Jürgen; Tamberg, Laura; Kiir, Carl Sander; Kranich, Laura; Timmusk, TõnisFrontiers in Molecular Neuroscience2022 / art. 1033224 https://doi.org/10.3389/fnmol.2022.1033224 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promotersSirp, Alex; Leite, Kristian; Tuvikene, Jürgen; Nurm, Kaja; Sepp, Mari; Timmusk, TõnisScientific reports2020 / art. 18424 https://doi.org/10.1038/s41598-020-75437-3 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophreniaSirp, Alex; Roots, Kaisa; Nurm, Kaja; Tuvikene, Jürgen; Sepp, Mari; Timmusk, TõnisThe journal of biological chemistry2021 / art. 101381 https://doi.org/10.1016/j.jbc.2021.101381 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular diseasePupina, Nadežda; Avarlaid, Annela; Sadam, Helle; Pihlak, Arno; Jaago, Mariliis; Tuvikene, Jürgen; Rähni, Annika; Planken, Anu; Planken, Margus; Kalso, Eija; Tienari, Pentti J.; Nieminen, Janne K.; Seppänen, Mikko R.J.; Vaheri, Antti; Lindholm, Dan; Sinisalo, Juha; Pussinen, Pirkko; Timmusk, Tõnis; Palm, KaiaeBioMedicine2022 / art. 103835, 14 p. : ill https://doi.org/10.1016/j.ebiom.2022.103835 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neuronsTuvikene, Jürgen; Esvald, Eli-Eelika; Rähni, Annika; Uustalu, Kaie; Zhuravskaya, Anna; Avarlaid, Annela; Makeyev, Eugene V.; Timmusk, TõniseLife2021 / art. e65161 https://doi.org/10.7554/eLife.65161 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Isoform-specific reduction of the basic helix-Loop-helix transcription factor TCF4 levels in Huntington's diseaseNurm, Kaja; Sepp, Mari; Castany-Pladevall, Carla; Creus-Muncunill, Jordi; Tuvikene, Jürgen; Sirp, Alex; Vihma, Hanna; Blake, Derek J.; Perez-Navarro, Esther; Timmusk, TõniseNeuro2021 / 53 p. : ill https://doi.org/10.1523/ENEURO.0197-21.2021 Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapiesRähni, Annika; Jaago, Mariliis; Sadam, Helle; Pupina, Nadežda; Pihlak, Arno; Tuvikene, Jürgen; Annuk, Margus; Mägi, Andrus; Timmusk, Tõnis; Ghaemmaghami, Amir M.; Palm, KaiaCommunications medicine2022 / 11 p. : ill https://doi.org/10.1038/s43856-022-00114-7

Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specifc phosphodiesterase 9ATaal, Kati; Tuvikene, Jürgen; Rullinkov, Grete; Piirsoo, Marko; Sepp, Mari; Neuman, Toomas; Tamme, Richard; Timmusk, TõnisScientific reports2019 / art. 7104, 12 p. : ill https://doi.org/10.1038/s41598-019-43069-x Journal metrics at Scopus Article at Scopus Journal metrics at WOS Article at WOS

PCSK9 deficiency alters brain lipid composition without affecting brain development and functionPärn, Angela; Olsen, Ditte; Tuvikene, Jürgen; Kaas, Mathias; Borisova, Ekaterina; Bilgin, Mesut; Elhauge, Mie; Vilstrup, Joachim; Madsen, Peder; Ambrozkiewicz, Mateusz C.; Goz, Roman U.; Timmusk, Tõnis; Tarabykin, Victor; Gustafsen, Camilla; Glerup, SimonFrontiers in molecular neuroscience2023 https://doi.org/10.3389/fnmol.2022.1084633

Rat NEURL1 3'UTR is alternatively spliced and targets mRNA to dendritesJaagura, Madis; Taal, Kati; Koppel, Indrek; Tuvikene, Jürgen; Timmusk, Tõnis; Tamme, RichardNeuroscience letters2016 / p. 71-76 : ill https://doi.org/10.1016/j.neulet.2016.10.041

Revisiting the expression of BDNF and its receptors in mammalian developmentEsvald, Eli-Eelika; Tuvikene, Jürgen; Kiir, Carl Sander; Avarlaid, Annela; Tamberg, Laura; Sirp, Alex; Shubina, Anastassia; Cabrera-Cabrera, Florencia; Pihlak, Arno; Koppel, Indrek; Palm, Kaia; Timmusk, TõnisFrontiers in Molecular Neuroscience2023 https://doi.org/10.3389/fnmol.2023.1182499

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2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilienceKumar, Amit; Karuppagounder, Saravanan S.; Chen, Yingxin; Corona, Carlo; Kawaguchi, Riki; Chen, Yuyan; Balkaya, Mustafa; Sagdullaev, Botir T.; Wen, Zhexing; Stuart, Charles; Cho, Sunghee; Ming, Guo-li; Tuvikene, Jürgen; Timmusk, Tõnis; Geschwind, Daniel H.; Ratan, Rajiv R.Neuron2023 / p. 2831-2846.e10 https://doi.org/10.1016/j.neuron.2023.06.013

Untranslated regions of brain-derived neurotrophic factor (Bdnf) mRNA control its translatability and subcellular localizationLekk, Ingrid; Cabrera-Cabrera, Florencia; Turconi, Giorgio; Tuvikene, Jürgen; Esvald, Eli-Eelika; Rähni, Annika; Casserly, Laoise; Garton, Daniel R.; Andressoo, Jaan-Olle; Timmusk, Tõnis; Koppel, IndrekThe journal of biological chemistry2023 / art. 102897 https://doi.org/10.1016/j.jbc.2023.102897