Research group of metalloproteomics

TalTech priority area
Research classification (Frascati)
Head of the research group
Wilson’s disease
The Research Group of Metalloproteomics is focused on the following topics: (1) structural andfunctional studies of metalloproteins participating in homeostasis of biometals: zinc, copper andiron by methods like NMR, ESI MS, ICP MS,fluorescence ja UV-VIS spectroscopy; (2) the role of biometals: zinc, copper and iron on fibrillization as well as on in vitro and in vivo toxicity ofamyloigogenic peptides linked with Alzheimer’sdisease; (3) design of new metal-chelating ligandsand elaboration of metal-chelating therapeuticstrategies for Wilsons and Alzheimer’s disease.Professor Palumaa is a member of the EuropeanMolecular Biology Organization (EMBO).
Important results
The most important achievements of the research group during last year were connectedwith the elucidation of the influence of α-lipoicacid on cellular copper metabolism and evaluation of its therapeutic potential in Alzheimer’sdisease insect models.
Kabin, E.; Dong, Y.; Roy, S.; Smirnova, J.; Smith, J. W; Ralle, M.; Summers, K.y; Yang, H.n; Dev, S.; Wang, Y.; Devenney, B.; Cole, R. N; Palumaa, P.; Lutsenko, S. (2023). α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance. Proceedings of the National Academy of Sciences, 120 (40), #e2305961120. DOI: 10.1073/pnas.2305961120.
Berntsson, E.; Vosough, F.; Noormägi, A.; Padari, K.; Asplund, F.; Gielnik, M.; Paul, S.; Jarvet, J.; Tõugu, V.; Roos, P. M; Kozak, M.; Gräslund, A.; Barth, A.; Pooga, M.; Palumaa, P.; Wärmländer, S. K T S (2023). Characterization of Uranyl (UO22+) Ion Binding to Amyloid Beta (Aβ) Peptides: Effects on Aβ Structure and Aggregation. ACS Chemical Neuroscience, 14 (15), 2618−2633. DOI: 10.1021/acschemneuro.3c00130.
Period of activity of the research group
Teadusgrupiga seotud publikatsioonid