Hüpertensiooni ja ateroskleroosi diagnostika ning ravi tehnoloogiate uurimisrühm
TalTech prioriteetne teadussuund
Klassifikaator (Frascati)
Kliiniline meditsiin 3.2
Uurimisrühma juht
Uurimisrühma liige
Doktorant
Võtmesõna
hüpertensioon
ateroskleroos
tehnoloogiad
diagnoosimine
ravi
Ülevaade
Uurimisrühma teaduskompetents hõlmab järgmisi valdkondi:• Südame- ja veresoonte haiguste diagnostika ja ravi tehnoloogiate uurimine ja rakendamine;• südame- ja veresoonkonna haigustega seotud teaduslikes uuringutes kasutatavate insenerilahenduste juurutamine meditsiinis;• uute kardiovaskulaarmeditsiini tehnoloogiate väljatöötamine ja kliiniline rakendamine;• varajase ateroskleroosi määramise uuringud ja seadmete juurutamine;• resistentse hüpertensiooni hemodünaamika uuringud ja innovatiivsete ravijuhtimise meetodite väljatöötamine;• kardiovaskulaarse riski (koos geeniriskiga) määramise ja langetamise uuringud;• perekondliku hüperkolesteroleemia diagnoosimise ja ravi uuringud. Uurimisrühm osaleb European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC). Uurimisrühm kuulub ka Euroopa Hüpertensiooniühingu Ektsellentsikeskuse hulka.
Tähtsamad tulemused
Uurimisrühm korraldas 25.-29. septembril 2023 Rahvusvahelise Aatomienergia Agentuuri ekspertmissiooni Tallinnas "Expert mission to advise on medical physics education, training and recognition“.
Seotud projektid
Perekondliku hüperkolesteroleemia diagnoosimise ja ravi uute tehnoloogiate väljatöötamine
Seotud struktuuriüksus
Publications related to the research group
- Banach, M., Reiner, Z., Cicero, A. F.G., Sabouret, P., Viigimaa, M., Sahebkar, A., Postadzhiyan, A., Gaita, D., Pella, D., Penson, P.E. 2022: The year in cardiovascular disease - the year of upfront lipid lowering combination therapy // Archives of Medical Science (2022) vol. 18, 6, p. 1429-1434 : ill.
https://doi.org/10.5114/aoms/156147 - Pikta, M., Szanto, T., Viigimaa, M., Lejniece, S., Balode, D., Saks, K., Banys, V. Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use // Journal of medical biochemistry (2021) vol. 40, 2, p. 167−172.
https://doi.org/10.5937/jomb0-26008 - Weber, T., Januszewicz, A., Rosei, E. A., Tsioufis, K., Okorie, M., Viigimaa, M. et al. The corona-virus disease 2019 pandemic compromised routine care for hypertension : a survey conducted among excellence centers of the European Society of Hypertension // Journal of hypertension (2021) Vol. 39, 1, p. 190-195.
https://doi.org/10.1097/HJH.0000000000002703 - Schwartz, G. G., Szarek, M., Bittner, V. A., Diaz, R., Goodman, S. G., ODYSSEY Outcomes Committees and Investigators, Viigimaa, M. et al. Lipoprotein(a) and Benefit of PCSK9 inhibition in patients with nominally controlled LDL cholesterol // Journal of the American College of Cardiology (2021) Vol. 78, 5, p. 421–433 : ill.
https://www.jacc.org/doi/epdf/10.1016/j.jacc.2021.04.102 https://doi.org/10.1016/j.jacc.2021.04.102 - Hagström, E., Steg, P.G., Szarek, M., Bhatt, D.L., Bittner, V.A., Danchin, N., Diaz, R., Goodman, S.G., Harrington, R.A., Jukema, J.W., Liberopoulos, E., Marx, N., Viigimaa, M. et al. Apolipoprotein B, residual cardiovascular risk after acute coronary syndrome, and effects of alirocumab // Circulation (2022) vol. 146, 9, p. 657 - 672.
https://doi.org/10.1161/CIRCULATIONAHA.121.057807 - Viigimaa, M., Jürisson, M., Pisarev, H., Kalda, R., Alavere, H., Irs, A., Saar, A., Fischer, K., Fischer, K., Kruuv-Käo, K., Mars, N., Widen, E., Ripatti, S., Metspalu, A. Effectiveness and feasibility of cardiovascular disease personalized prevention on high polygenic risk score subjects : a randomized controlled pilot study // European Heart Journal Open (2022) vol. 2, 6, Art. oeac079.
https://doi.org/10.1093/ehjopen/oeac079 - Viigimaa, M., Sachinidis, A., Toumpourleka, M., Koutsampasopoulos, K., Alliksoo, S., Titma, T. Macrovascular complications of type 2 diabetes mellitus // Current Vascular Pharmacology (2020) vol. 18, 2, p. 110 - 116 : ill.
https://doi.org/10.2174/1570161117666190405165151 - Walsh, I., Fishman, D., Garcia-Gasulla, D., Titma, T., Pollastri, G., ELIXIR Machine Learning Focus Group, Harrow, J., Psomopoulos, F. E., Tosatto, S. C. E. DOME : recommendations for supervised machine learning validation in biology // Nature methods (2021) vol. 18, p. 1122–1127.
https://doi.org/10.1038/s41592-021-01205-4 - Ossenkoppele, R., Reimand, J., Smith, R., Leuzy, A., Strandberg, O., Palmqvist, S., Stomrud, E., Zetterberg, H. Tau PET correlates with different Alzheimer’s disease-related features compared to CSF and plasma p-tau biomarkers // EMBO Molecular Medicine (2021) vol. 13, 8, art. e14398.
https://doi.org/10.15252/emmm.202114398 - Broman, K. K., Hughes, T., Dossett, L., Sun, J., Kirichenko, D., Carr, M. J., Sharma, A., Bartlett, E. K., Nijhuis, A. A. G., Thompson, J. F., Teras, J., Teras, R. M. et al. Active surveillance of patients who have sentinel node positive melanoma : an international, multi‐institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy trial II (MSLT‐2) // Cancer (2021) vol. 127, 13, p. 2251-2261.
https://doi.org/10.1002/cncr.33483 - Charlton, P. H., Paliakaite, B., Pilt, K., Bachler, M., Zanelli, S., Kulin, D., Allen, J., Hallab, M., Bianchini, E., Mayer, C. C. et al. Assessing hemodynamics from the photoplethysmogram to gain insights into vascular age : a review from VascAgeNet // American journal of physiology-heart and circulatory physiology (2022) vol. 322, 4, p. H493-H522.
https://doi.org/10.1152/ajpheart.00392.2021 - Reimand, J., Collij, L., Scheltens, P. et al. Association of amyloid-β CSF/PET discordance and tau load 5 years later // Neurology (2020) vol. 95, 19, p. e2648-e2657 : ill.
https://doi.org/10.1212/WNL.0000000000010739 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963352/ - Visser, D., Wolters, E.E., Verfaillie, S.C.J., Reimand, J. et al. Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease // European journal of nuclear medicine and molecular imaging (2020) vol. 47, p. 3165–3175.
https://doi.org/10.1007/s00259-020-04831-w - Collij, L. E., Salvadó, G., Shekari, M., Lopes Alves, I., Reimand, J., Wink, A. M., Zwan, M., Niñerola-Baizán, A., Perissinotti, A., Scheltens, P. et al. Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent // European journal of nuclear medicine and molecular imaging (2021) vol. 48, 7, p. 2169–2182.
https://doi.org/10.1007/s00259-020-05174-2 - Reimand, J., Boon, B.D.C., Collij, L.E. et al. Amyloid-beta PET and CSF in an autopsy-confirmed cohort // Annals of clinical and translational neurology (2020) vol. 7, 11, p. 2150−2160.
https://doi.org/10.1002/acn3.51195 - Broman, K. K., Hughes, T. M., Dossett, L. A., Sun, J., Carr, M. J., Kirichenko, D. A., Sharma, A., Bartlett, E. K., Nijhuis, Amanda AG., Teras, R., Teras, J. et al. Surveillance of sentinel node-positive melanoma patients with reasons for exclusion from MSLT-II: Multi-institutional propensity score matched analysis // Journal of the American College of Surgeons (2021) vol. 232, 4, p. 424-431.
https://doi.org/10.1016/j.jamcollsurg.2020.11.014 - Paats, J., Arund, J., Fridolin, I., Leis, L., Luman, M., Pilt, K., Uhlin, F. et al. Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients // International journal of molecular sciences (2020) vol. 21, 4, art. 1522, 19 p. : ill.
https://doi.org/10.3390/ijms21041522 - Teras, J., Kroon, H. M., Miura, J.T. et al. International multicenter experience of isolated limb infusion for in-transit melanoma metastases in octogenarian and nonagenarian patients // Annals of surgical oncology (2020) vol. 27, 5, p. 1420-1429.
https://doi.org/10.1245/s10434-020-08312-0 - Kenyon-Smith, T.J., Kroon, H.M., Miura, J.T., Teras, J. et al. Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study // European journal of surgical oncology (2020) vol. 46, 11, p. 2140-2146.
https://doi.org/10.1016/j.ejso.2020.06.040 - Boyko, A., Therapontos, C., Horakova, D., Gross-Paju, K. et al. Approaches and challenges in the diagnosis and management of secondary progressive multiple sclerosis : a Central Eastern European perspective from healthcare professionals // Multiple sclerosis and related disorders (2021) vol. 50, art. 102778, 12 p. : ill.
https://doi.org/10.1016/j.msard.2021.102778 - Reimand, J., Groot, C., Teunissen, C.E. et al. Why is amyloid-β PET requested after performing CSF biomarkers? // Journal of Alzheimer's disease (2020) vol. 73, 2, p. 559-569.
https://doi.org/10.3233/JAD-190836 - Charlton, P.H., Pilt, K., Kyriacou, P.A. Establishing best practices in photoplethysmography signal acquisition and processing // Physiological measurement (2022) vol. 43, 5, art. 050301, 6 p.
https://doi.org/10.1088/1361-6579/ac6cc4 - Gross-Paju, K., Thomson, U., Adlas, R., Jaakmees, H., Kannel, K., Mallene, S. M., Mironenko, S., Reitsnik, A., Vares, A., Ütt, S. Implementation of the Helsinki Model at West Tallinn Central Hospital // Medicina (2022) vol. 58, 9, art. 1173.
https://doi.org/10.3390/medicina58091173 - Zemtsovskaja, G., Pilt, K., Samarin, A., Abina, J., Meigas, K., Viigimaa, M. Construction of gender-specific regression models for aortic length estimation based on computed tomography images // Health and technology (2020) vol. 10, p. 679–687 : ill.
https://doi.org/10.1007/s12553-019-00391-8 - Teras, J., Kroon, H.M., Zager, J.S. ASO author reflection : isolated limb infusion for locally advanced melanoma in the extremely old patient is safe and effective // Annals of surgical oncology (2020) Vol. 27, 5, p. 1430-1431.
https://doi.org/10.1245/s10434-020-08314-y https://link.springer.com/article/10.1245/s10434-020-08314-y - Pilt, K., Arund, J., Adoberg, A., Leis, L., Luman, M., Fridolin, I. Online urea concentration estimation from spent dialysate using optical sensor // XV Mediterranean Conference on Medical and Biological Engineering and Computing - MEDICON 2019 : proceedings of MEDICON 2019, September 26–28, 2019, Coimbra, Portugal. Cham : Springer, 2020. p. 1459-1464. (IFMBE proceedings ; 76).
https://doi.org/10.1007/978-3-030-31635-8_180 - Teras, J., Carr, M.J., Zager, J.S. et al. Molecular aspects of the isolated limb infusion procedure // Biomedicines (2021) vol. 9, 2, art. 163, 13 p. : ill.
https://doi.org/10.3390/biomedicines9020163 - Teras, J., Teras, M., Pata P., Mägi A., et al. First Eastern European experience of isolated limb infusion for in-transit metastatic melanoma confined to the limb: Is it still an effective treatment option in the modern era? // European journal of surgical oncology (2020) vol. 46, 2, p. 272-276.
https://doi.org/10.1016/j.ejso.2019.10.039 - Walsh, I., Fishman, D., Garcia-Gasulla, D., Titma, T., Pollastri, G. et al. Author Correction : DOME : recommendations for supervised machine learning validation in biology // Nature methods (2021) Vol. 18, p. 1409–1410 : ill.
https://doi.org/10.1038/s41592-021-01304-2 - Allik, A., Pilt, K., Viigimäe, M., Fridolin, I. Pilot study for estimating physical fatigue based on heart rate variability and reaction time // XV Mediterranean Conference on Medical and Biological Engineering and Computing -MEDICON 2019 : proceedings of MEDICON 2019, September 26–28, 2019, Coimbra, Portugal. Cham : Springer, 2020. p. 193-200. (IFMBE proceedings ; 76).
https://doi.org/10.1007/978-3-030-31635-8_23 - Pilt, K., Karai, D., Bachmann, M., Gavriljuk, M., Allik, A., Uudeberg, T. Influence of mental stress on the arterial stiffness parameters detected from photoplethysmographic signal waveform // 2022 18th Biennial Baltic Electronics Conference (BEC). : IEEE, 2022. 4 p.
https://doi.org/10.1109/BEC56180.2022.9935609 - Kööts, K., Pilt, K., Sepa, M., Pikta, M., Fridolin, I., Meigas, K., Viigimaa, M. Assessment of associations between arterial mechanical properties and biochemical blood markers for early detection of atherosclerosis // 8th European Medical and Biological Engineering Conference : proceedings of the EMBEC 2020, November 29 – December 3, 2020 Portorož, Slovenia. Cham : Springer, 2021. p. 121-129. (IFMBE proceedings ; 80).
https://doi.org/10.1007/978-3-030-64610-3_15 - Pilt, K., May, J. M., Kyriacou, P. A. In-vitro investigation of flow profiles in arteries using the photoplethysmograph // Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). : IEEE, 2021. p. 7211-7214.
https://doi.org/10.1109/EMBC46164.2021.9629713 - Shin, M.-J., Veskioja, T., Titma, T., Samoson, A. Kemeny-Snell distance in nuclear magnetic resonance metabolomics // Applied magnetic resonance (2020) vol. 51, 12, p. 1637−1645.
https://doi.org/10.1007/s00723-020-01282-2 - Adoberg, A., Paats, J., Arund, J., Dhondt, A., Fridolin, I., Glorieux, G., Holmar, J., Lauri, K., Leis, L., Luman, M., Pilt, K., Uhlin, F., Tanner, R. Treatment with paracetamol can interfere with the intradialytic optical estimation in spent dialysate of uric acid but not of indoxyl sulfate // Toxins (2022) vol. 14, 9, art. 610.
https://doi.org/10.3390/toxins14090610 - Allik, A., Pilt, K., Viigimäe, M., Fridolin, I., Jervan, G. A novel physical fatigue assessment method utilizing heart rate variability and pulse arrival time towards personalized feedback with wearable sensors // Sensors (2022) vol. 22, 4, art. 1680.
https://doi.org/10.3390/s22041680 - Allik, A., Mägi, S., Pilt, K., Karai, D., Fridolin I., Leier, M., Jervan, G. Comparison of predictive equations for basal metabolic rate // Wireless Mobile Communication and Healthcare : 7th International Conference, MobiHealth 2017, Vienna, Austria, November 14–15, 2017 : proceedings. Cham : Springer, 2018. p. 261-264 : ill. (Lecture notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering ; 247).
https://doi.org/10.1007/978-3-319-98551-0 - Allik, A., Pilt, K., Karai, D., Fridolin, I., Leier, M., Jervan, G. Classification algorithm improvement for physical activity recognition in maritime environments // World Congress on Medical Physics and Biomedical Engineering 2018 : June 3–8, 2018, Prague, Czech Republic (Vol. 3). Singapore : Springer Nature, 2019. p. 13-17. (IFMBE proceedings ; 68/3).
https://doi.org/10.1007/978-981-10-9023-3_3 - Einstein, S., Pilt, K., Palmar, M., Meigas, K., Viigimaa, M. Aortic augmentation index is dependent on bodyside in healthy young subjects // High Blood Pressure & Cardiovascular Prevention (2019) vol. 26, p. 375–382 : ill.
https://doi.org/10.1007/s40292-019-00335-3 - Titma, T., Shin, M-J., Ludwig, C., Günther, U., Pikta, M., Zemtsovskaja, G., Viigimaa, M., Tanner, R., Samoson, A. The metabolic profile of stable ischemic heart disease by serum 1H NMR // Applied magnetic resonance (2019) vol. 50, 4, p. 527–539 : ill.
https://doi.org/10.1007/s00723-018-1084-0 - Pilt, K., Silluta, S., Palmar, M., Karai, D., Meigas, K., Viigimaa, M. Second derivative photoplethysmographic signal analysis of differences between fingers in healthy subjects [Online resource] // BEC 2018 : 2018 16th Biennial Baltic Electronics Conference (BEC) : proceedings of the 16th Biennial Baltic Electronics Conference, October 8-10, 2018. : IEEE, 2019. 4 p.: ill.
https://doi.org/10.1109/BEC.2018.8600985 - Teras, J., Magi, A., Teras, M., Pata, P. et al. Soft tissue cancer management: isolated limb infusion for sarcoma // Visceral medicine (2019) vol. 35, 6, p. 373-379 : ill.
https://doi.org/10.1159/000495888 - Leier, M., Jervan, G., Allik, A., Pilt, K., Karai, D., Fridolin, I. Fall detection and activity recognition system for usage in smart work-wear [Online resource] // BEC 2018 : 2018 16th Biennial Baltic Electronics Conference (BEC) : proceedings of the 16th Biennial Baltic Electronics Conference, October 8-10, 2018. : IEEE, 2018. 4 p.: ill.
https://doi.org/10.1109/BEC.2018.8600959 - Talvik, A., Rebora, P., Heinpalu-Kuum, M., Viigimaa, M. et al. Non-invasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients: effects on home blood pressure in the BEAUTY study // Blood pressure (2018) vol. 27, 6, p. 368-375.
https://doi.org/10.1080/08037051.2018.1505425 - Allik, A., Pilt, K., Karai, D., Fridolin, I., Leier, M., Jervan, G. Optimization of physical activity recognition for real-time wearable systems : effect of window length, sampling frequency and number of features // Applied sciences (2019) vol. 9, 22, art. 4833, 14 p. : ill.
https://doi.org/10.3390/app9224833 - Titma, T. The effect of surface charge and pH on the physiological behaviour of cobalt, copper, manganese, antimony, zinc and titanium oxide nanoparticles in vitro // Toxicology in vitro (2018) vol. 50, p. 11-21 : ill.
https://doi.org/10.1016/j.tiv.2018.02.010 - Kuusik, A., Alam, M.M., Kask, T., Gross-Paju, K. Wearable m-assessment system for neurological disease patients // Proceedings : IEEE 4th World Forum on Internet of Things. [S.l.] : IEEE, 2018. p. 201-206 : ill.
https://doi.org/10.1109/WF-IoT.2018.8355165 - Paalme, V., Rump, A., Mädo, K., Teras, M., Truumees, B., Aitai, H., Ratas, K., Teras, J., Rüütel Boudinot, S. et al. Human peripheral blood eosinophils express high levels of the purinergic receptor P2X4 // Frontiers in immunology (2019) vol. 10, art. 2074, 15 p. : ill.
https://doi.org/10.3389/fimmu.2019.02074 - Reimand, J., de Wilde, A., Teunissen, C. E., Zwan, M. et al. PET and CSF amyloid-β status are differently predicted by patient features: Information from discordant cases // Alzheimer's Research & Therapy (2019) vol. 11, 1, art. 100, 16 p. : ill.
https://doi.org/10.1186/s13195-019-0561-5 - Utjés, D., Malmstedt, J., Teras, J. et al. 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial // The Lancet (2019) vol. 394, 10197, p. 471−477.
https://doi.org/10.1016/S0140-6736(19)31132-8 - Wilde, A. de, Reimand, J., Teunissen, C. E., Zwan, M. et al. Discordant amyloid-β PET and CSF biomarkers and its clinical consequences // Alzheimer's Research & Therapy (2019) vol. 11, 1, art. 78, 13 p. : ill.
https://doi.org/10.1186/s13195-019-0532-x - Kalokairinou, L., Howard, H.C., Slokenberga, S., Fisher, E., Titma, T. et al. Legislation of direct-to-consumer genetic testing in Europe : a fragmented regulatory landscape // Journal of community genetics (2018) vol. 9, 2, p. 117-132.
https://doi.org/10.1007/s12687-017-0344-2 - Collij, L.E., Konijnenberg, E., Reimand, J., Kate, M. ten, den Braber, A., Alves, I.L., Zwan, M., Yaqub, M., van Assema, D.M.E., Wink, A.M. et al. Assessing amyloid pathology in cognitively normal subjects using 18F-flutemetamol PET : comparing visual reads and quantitative methods // Journal of nuclear medicine (2019) vol. 60, 4, 7 p. : ill.
https://doi.org/10.2967/jnumed.118.211532 - Bar-Or, A., Wiendl, H., Montalban, X., Alvarez, E., Davydovskaya, M., Delgado, S. R., Evdoshenko, E. P., Giedraitiene, N., Gross-Paju, K., Haldre, S. et al. Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis : APLIOS, a randomized phase-2 study // Multiple Sclerosis Journal (2022) vol. 28, 6, p. 849-1002.
https://doi.org/10.1177/13524585211044479 - Sarv, S., Kahre, T., Vaidla, E., Pajusalu, S., Muru, K., Põder, H., Gross-Paju, K., Ütt, S., Žordania, R., Talvik, I. et al. The birth prevalence of spinal muscular atrophy: a population specific approach in Estonia // Frontiers in genetics (2021) vol. 12, art. 796862.
https://doi.org/10.3389/fgene.2021.796862 - Kõrv, J., Antsov, K., Gross-Paju, K., Kalju, I., Kreis, A., Liigant, A., Vibo, R. Developments in quality of stroke care in Estonia // European Stroke Journal (2023) Vol. 8, Issue 1_suppl., p. 35-43.
https://doi.org/10.1177/23969873221110745 - Paats, J., Adoberg, A., Arund, J., Dhondt, A., Fernström, A., Fridolin, I. Glorieux, G., Holmar, J., Luman, M., Pilt, K. Time-averaged concentration estimation of uraemic toxins with different removal kinetics : a novel approach based on intradialytic spent dialysate measurements // Clinical Kidney Journal (2023) vol. 16, 4, p. 735-744 : ill.
https://doi.org/10.1093/ckj/sfac273 https://academic.oup.com/ckj/article/16/4/735/6948331 - Gavriljuk, M., Uudeberg, T., Pilt, K., Karai, D., Fridolin, I., Bachmann, M. Electroencephalography as an objective indicator of stress // 19th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics : Proceedings of NBC 2023, June 12–14, 2023, Liepaja, Latvia. : Springer, 2023. p. 221–226. (IFMBE Proceedings ; 89).
https://doi.org/10.1007/978-3-031-37132-5_28 - Rump, A., Ratas, K., Lepasepp, T. K., Suurväli, J., Smolander, O‐P., Gross‐Paju, K., Toomsoo, T., Kanellopoulos, J., Rüütel Boudinot, S. Sex‐dependent expression levels of VAV1 and P2X7 in PBMC of Multiple Sclerosis patients // Scandinavian journal of immunology (2023) vol. 98, 2, art. e13283, 15 p. : ill.
https://doi.org/10.1111/sji.13283 - Vallejo-Vaz, A. J., Stevens, C. A. T., Lyons, A. R. M., Dharmayat, K. I., Freiberger, T., Hovingh, G. K., Mata, P., Raal, F. J., Santos, R. D., Viigimaa, M. et al. Global perspective of familial hypercholesterolaemia : a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) // The Lancet (2021) vol. 398, 10312, p. 1713-1725.
https://doi.org/10.1016/S0140-6736(21)01122-3